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  • Novel Biophotonic Techniques and Applications II
  • SPIE Proceedings (Optica Publishing Group, 2013),
  • paper 88010C

High-resolution deep-tissue optical imaging using anti-Stokes phosphors

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Abstract

We report on the high-resolution deep-tissue imaging using novel water-dispersible upconversion nanoparticles (UCNPs) β-NaYF4:Yb3+:Tm3+. Luminescence from the UCNP embedded into tissue-mimicking phantoms at the depth of 4 mm epi-illuminated with 975-nm laser radiation was detected. Fiber-optic detection shows 2-times better resolution compared with that obtained using CCD-based imaging modality. The conversion efficiency of upconversion particles and their cytotoxicity to HeLa cells were also investigated and reported.

© 2013 SPIE

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