Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group
  • Optical Coherence Tomography and Coherence Techniques VI
  • SPIE Proceedings (Optica Publishing Group, 2013),
  • paper 88020P

In-vivo imaging of keratoconic corneas using high-speed high-resolution swept-source OCT

Not Accessible

Your library or personal account may give you access

Abstract

Keratoconus (KC) is a progressive degenerative corneal disease that can lead to a strong deformation of the cornea and loss of clarity, causing distorted or blurred vision. Surgical treatment for severe cases requires precise evaluation of the corneal curvature, thickness, layer structure, and clarity. Current clinical instruments for assessing the corneal shape cannot resolve the internal structure, and high-resolution microscopy techniques are limited to a small field of view. We have implemented a swept-source OCT (SS-OCT) system that enables high-speed imaging (100 kA-scans/s) of the entire cornea and provides ~5.1 μm axial resolution in corneal tissue. With an imaging range of 5.6 mm (in air), we can cover the full length from the cornea’s apex to the anterior surface of the lens. We have acquired volumetric corneal images from human subjects with different stages of KC and from subjects who underwent surgery or cross-linking therapy. We developed an automatic algorithm for segmenting the outer and inner surfaces of the cornea in the images which will enable precise measurement of the corneal curvature and thickness. This makes SS-OCT an ideal instrument for comprehensive examination of keratoconic corneas.

© 2013 SPIE

PDF Article
More Like This
Quantitative analysis of the human cornea using high-speed swept source OCT

K. Karnowski, M. Gora, B.J. Kaluzny, D. Rumiński, S. Orłowski, A. Kowalczyk, and M. Wojtkowski
JMA46 Biomedical Optics (BIOMED) 2010

Akinetic swept-source technology for high speed OCT with unprecedented coherence length

B. Zabihian, M.P. Minneman, M. Bonesi, J. Ensher, H. Sattmann, S. Gray, R.A. Leitgeb, M. Crawford, and W. Drexler
BT3A.2 Bio-Optics: Design and Application (BODA) 2013

Polarization-resolved SHG imaging of lamellar organization in keratoconic human corneas

Clothilde Raoux, Margaux Schmeltz, Marion Bied, Maged Alnawaiseh, Uwe Hansen, Gaël Latour, and Marie-Claire Schanne-Klein
EM3B.1 European Conference on Biomedical Optics (ECBO) 2021

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved