Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Oxygenation Level and Hemoglobin Concentration in Experimental Tumor Estimated by Diffuse Optical Spectroscopy

Not Accessible

Your library or personal account may give you access

Abstract

Using diffuse optical spectroscopy the level of oxygenation and hemoglobin concentration in experimental tumor in comparison with normal muscle tissue of mice have been studied. Subcutaneously growing SKBR-3 was used as a tumor model. Continuous wave fiber probe diffuse optical spectroscopy system was employed. Optical properties extraction approach was based on diffusion approximation. Decreased blood oxygen saturation level and increased total hemoglobin content were demonstrated in the neoplasm. The main reason of such differences between tumor and norm was significant elevation of deoxyhemoglobin concentration in SKBR-3. The method can be useful for diagnosis of tumors as well as for study of blood flow parameters of tumor models with different angiogenic properties.

© 2017 SPIE

PDF Article
More Like This
A technique for measuring oxygen saturation in biological tissues based on diffuse optical spectroscopy

Mikhail Kleshnin, Anna Orlova, Mikhail Kirillin, German Golubiatnikov, and Ilya Turchin
1041212 European Conference on Biomedical Optics (ECBO) 2017

Quantitative Diffuse Optical Spectroscopy of Short-term Reoxygenation Kinetics in Radiation-Resistant and Sensitive Tumors

Paola Monterroso Díaz, Daria Semeniak, Kinan Alhallak, Dakory Lee, Ruud P.M. Dings, and Narasimhan Rajaram
OmW3D.2 Optical Molecular Probes, Imaging and Drug Delivery (OMP) 2017

Hemoglobin spectra and employed wavelengths affect estimation of concentration and oxygen saturation: blood-lipid phantom study

Aleh Sudakou, Anna Gerega, Helene Isler, Piotr Sawosz, Daniel Ostojic, Martin Wolf, and Adam Liebert
ES2B.7 European Conference on Biomedical Optics (ECBO) 2021

References

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an Optica member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Login to access Optica Member Subscription

Select as filters


Select Topics Cancel
© Copyright 2022 | Optica Publishing Group. All Rights Reserved