Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol.

Anne Planat-Chrétien; M. Berger; Samuel Wanji; Michel Boussinesq; Belen Pedrique; Jean-Marc Dinten

doi:10.1117/12.2286051

Diffuse Optical Spectroscopy and Imaging VI
SPIE Proceedings (Optica Publishing Group, 2017),
paper 104120I
•https://doi.org/10.1117/12.2286051

Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol.

Anne Planat-Chrétien, M. Berger, Samuel Wanji, Michel Boussinesq, Belen Pedrique, and Jean-Marc Dinten

European Conference on Biomedical Optics 2017

Munich Germany
25–29 June 2017
ISBN: 9781510612822

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Advances in Instrumentation and Technology III (AITIII)

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A. Planat-Chrétien, M. Berger, S. Wanji, M. Boussinesq, B. Pedrique, and J. Dinten, "Assessment of the status of onchocerciasis worms with DRS: proposal of a standardized measurement protocol.," in Diffuse Optical Spectroscopy and Imaging VI, H. Dehghani, ed., Vol. 10412 of SPIE Proceedings (Optica Publishing Group, 2017), paper 104120I.

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Abstract

In the present work, we show the capacity of spatially resolved Diffuse Reflectance Spectroscopy (DRS) to identify live and dead worms in ex vivo Onchocerca ochengi nodules. It demonstrates the potential of DRS to diagnose the worm state and to monitor the effect of a drug on macrofilariae. These results have been obtained in constrained conditions, leading to the proposal of a rigorous acquisition and analysis protocol that may contribute to standardized measures in diffuse optics.

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