Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Objective and quantitative analysis of corneal transparency with clinical spectral-domain optical coherence tomography

Not Accessible

Your library or personal account may give you access

Abstract

Lack of corneal transparency is a major cause of blindness worldwide. However, means to assess corneal transparency are limited and in current clinical and eye-bank practice usually involve a subjective and qualitative observation of opacities, sometimes with comparison against an arbitrary grading scale, by means of slit-lamp biomicroscopy. To address this unmet need, we have developed a method for corneal transparency assessment based on a new optical data analysis-based approach. Our method allows the objective extraction of quantitative parameters (including the scattering mean-free path, ls, a major indicator of scattering extent and thus of transparency of a medium) based on a physical model of corneal transparency and has been validated by laboratory experiments, using high-resolution, ex-vivo “full-field” optical coherence tomography (FF-OCT). Here, we apply our algorithm to depth-resolved spectral domain OCT (SD-OCT) images of in-vivo corneas and demonstrate the feasibility of our approach by means of four representative clinical cases. Specifically, we illustrate its potential in discriminating between the four clinical cases and, if applicable, deriving the scattering mean-free path as a quantitative measure of corneal transparency from objective analysis of stromal light backscattering (attenuation of the coherent mean) with SD-OCT. This measure may be related to, or expressed as, Strehl ratio reduction and thus retinal PSF broadening. As such, our approach not only has the potential to supply the demand for an objective means to quantify corneal transparency in the clinical setting, but also to create an association with visual function.

© 2019 SPIE/OSA

PDF Article
More Like This
Quantitative Measures of Corneal Transparency, Derived from Objective Analysis of Stromal Light Backscattering with Full-Field Optical Coherence Tomography

Romain Bocheux, Pascal Pernot, Vincent Borderie, Karsten Plamann, and Kristina Irsch
ITh2B.5 Imaging Systems and Applications (IS) 2019

Objective Characterisation of Corneal Transparency by Analysis of Clinical SD-OCT Images

Maëlle Vilbert, Romain Bocheux, Cristina Georgeon, Vincent Borderie, Pascal Pernot, Kristina Irsch, and Karsten Plamann
126320U European Conference on Biomedical Optics (ECBO) 2023

Towards Objective Corneal Transparency Assessment in the Clinical Setting: Correction of Acquisition Artifacts in Spectral-domain OCT Images

Maëlle Vilbert, Romain Bocheux, Hugo Lama, Cristina Georgeon, Vincent Borderie, Pascal Pernot, Kristina Irsch, and Karsten Plamann
ITu1D.5 Imaging Systems and Applications (IS) 2021

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved