Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements

Not Accessible

Your library or personal account may give you access

Abstract

Time-resolved (TR) techniques are exploited in many biomedical applications in order to find absolute values of absorption (µa) and reduced scattering (µs’) coefficients that characterize biological tissues chemical and microstructure properties. However, the concomitant acquisition of tissue distribution time-of-flight (DTOF) and instrument response function (IRF) is necessary to perform quantitative measurements. This can be a non-trivial time consuming operation which typically requires to detach the optical fibers from the measurement probe (usually put in a reflectance configuration for in-vivo applications) in order to face them one to each other (“reference” geometry). To overcome these difficulties, a new IRF measurement method that exploit the “reflectance” geometry is here proposed. A practical 3D printed implementation has been carried out for a specific device to test the feasibility of this approach and if the IRF acquired in the “reflectance” geometry is equivalent to the “reference” one. A particular problem addressed is the determination of the temporal shift T0 that can occur between IRF and sample DTOF. Two different approaches, based respectively on the curves barycenters difference and on a calibration phantom, are proposed. Both methods are valid and indifferently applicable according to specific measurement requirements. This allows “reflectance” IRF acquisition to be eligible as standard methodology for TR measurements.

© 2019 SPIE/OSA

PDF Article
More Like This
Large area SiPM and high throughput timing electronics: toward new generation time-domain instruments

Anurag Behera, Laura Di Sieno, Sumeet Rohilla, Antonio Pifferi, Alessandro Torricelli, Davide Contini, Benedikt Krämer, Felix Koberling, and Alberto Dalla Mora
11074_1 European Conference on Biomedical Optics (ECBO) 2019

Time-Resolved multi-wavelength, dual-channel system for diffuse optical spectroscopy: performance assessment

Marta Zanoletti, Marco Renna, Mauro Buttafava, Anurag Behera, Pranav Lanka, Laura Di Sieno, Alberto Dalla Mora, Alberto Tosi, and Davide Contini
11074_98 European Conference on Biomedical Optics (ECBO) 2019

Performance evaluation of time-domain multispectral diffuse optical tomography in the reflection geometry

Judy Zouaoui, Laura Di Sieno, David Orive-Miguel, Lionel Hervé, Antonio Pifferi, Andrea Farina, Alberto Dalla Mora, Jacques Derouard, Jérôme Mars, Laurent Condat, and Jean-Marc Dinten
1041208 European Conference on Biomedical Optics (ECBO) 2017

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved