Abstract

Optical coherence tomography (OCT) is a non-invasive imaging technique which is currently investigated for intraoperative detection of residual tumor during resection of human gliomas. Three different OCT systems were used for imaging of human glioblastoma in vivo (830nm spectral domain (SD) OCT integrated into a surgical microscope) and ex vivo (940nm SD-OCT and 1310nm swept-source MHz-OCT using a Fourier domain mode locked (FDML) laser). Before clinical data acquisition, the systems were characterized using a three-dimensional point-spread function phantom. To distinguish tumor from healthy brain tissue later on, attenuation coefficients of each pixel in OCT depth profiles are calculated. First examples from a clinical study show that the pixel-resolved calculation of the attenuation coefficient provides a good image contrast and confirm that white matter shows a higher signal and more homogeneous signal structure than tumorous tissue.

© 2019 SPIE/OSA