Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Dosimetry for microsecond selective laser trabeculoplasty

Not Accessible

Your library or personal account may give you access

Abstract

Selective Laser Trabeculoplasty (SLT) is a treatment option for open-angle glaucoma, however, it lacks an instant evidence for successful irradiation. So far ophthalmologists use the visible appearance of permanent champagne like bubbles as an indicator for appropriate pulse energy. We hypothesize that micro bubbles, which take place far below the appearance of macro bubbles already trigger the therapeutic benefit. Here we present two techniques for real-time detection of the onset of micro bubbles. The trabecular meshwork of freshly enucleated porcine eye globes was irradiated, in contrast to conventional SLT, with a series of 15 pulses with a pulse duration of 1.7 μs and with increasing energy at a repetition rate of 100 Hz per each spot of 200 μm in diameter. Both observation methods, an optoacoustic and an optical, are equally capable of detecting micro bubble nucleation, with sensitivities over 0.83 and specificities over 0.89. We demonstrated an accurate method for detection of micro bubble formation in SLT. In case that the therapeutically demanded pressure reduction is already achieved with these micro bubbles, which needs to be proved clinically, then the methods presented here can be used in a feedback loop controlling the laser irradiation. This will unburden the clinicians from any dosing during SLT.

© 2019 SPIE/OSA

PDF Article
More Like This
Optical coherence tomography controlled selective retina therapy with a novel microsecond laser

Christian Burri, Alessa Hutfilz, Lorenz Grimm, Patrik Arnold, Ralf Brinkmann, Dirk Theisen-Kunde, Andreas Ebneter, Boris Považay, and Christoph Meier
11079_2 European Conference on Biomedical Optics (ECBO) 2019

Interferometric Optical Online Dosimetry for Selective Retina Treatment (SRT)

Hardo Stoehr, Lars Ptaszynski, Andreas Fritz, and Ralf Brinkmann
6632_29 European Conference on Biomedical Optics (ECBO) 2007

Comparison of acoustic transients with fringe washouts of OCT M-scans during RPE microsecond laser irradiation

Christian Burri, Mylène Amstutz, Leonie Hoffmann, Simon Salzmann, Christoph Meier, Boris Považay, and Martin Frenz
126271L European Conference on Biomedical Optics (ECBO) 2023

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved