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Red and blue light photodynamic therapy regimes: optical monitoring and histology studies

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Abstract

In this study we present a complex approach to photodynamic therapy (PDT) with chlorin based photosensitizers including Monte Carlo based planning and prediction of optical diagnostics results, intra-procedure dual-wavelength fluorescence monitoring allowing to evaluate PS accumulation and photobleaching, and monitoring of tissue response with optical coherence tomography (OCT). The approach was employed to compare the effects of different PDT regimens in normal and tumor tissues and the results of non-invasive optical diagnostics were matched with results of histologic examination, including hematoxylin-eosin and Mallory staining. The considered doses are in the range 50-150 J/cm2 for normal tissues and 150-275 J/cm2 for tumor tissues, single wavelength (405 and 660 nm) and dual-wavelength regimes are studied.

© 2019 SPIE/OSA

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