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Dual-wavelength fluorescence localization of chlorin-based photosensitizer

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Photodynamic therapy (PDT) proved itself as a powerful tumor and non-tumor pathologies treatment tool. Photosensitizers (PS), which are employed as therapeutic agents for PDT, feature fluorescent properties. Thus, PDT provides the principles of theranostics when diagnostics is performed during treatment. The estimation of PS localization within the tissue is of critical importance for PDT planning. Fluorescence imaging is commonly applied for the monitoring of PS accumulation within the tissue, however, it does not provide with the in-depth PS distribution. Chlorin-based PS feature two pronounced peaks in their excitation spectra corresponding to 402 nm and 662 nm, which provides additional diagnostic possibilities. The ratio of fluorescence signals corresponding to different excitation wavelengths is shown to be a criterion for the evaluation of PS penetration depth after topical application and PS localization within the tissue after intravenous injection. The study is based on numerical simulation applying Monte Carlo technique. The results of numerical simulations are verified with phantom experiments results.

© 2019 SPIE/OSA

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