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Comparative analysis of single- and dual-wavelength low dose photodynamic therapy regimens

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Dual-wavelength photodynamic therapy is a photodynamic therapy (PDT) modality combining therapeutic effects of irradiation at two wavelengths of different region of visible range. In this paper we report on comparative analysis of single- and dual-wavelength PDT regimes based on multimodal optical monitoring of tissue response with histologic verification. Morphological and functional tissue responses to PDT procedure with chlorin-based photosensitizer (PS) were studied at the normal skin of a rabbit ear inner surface. Multimodal optical monitoring was performed by OCT and dual-wavelength fluorescence technique. The studied doses vary from 50 to 150 J/cm2 delivered separately at 405 or 660 nm, or at both wavelengths together in the equal dose.

© 2019 SPIE/OSA

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