Abstract
Dual-wavelength photodynamic therapy is a photodynamic therapy (PDT) modality combining therapeutic effects of irradiation at two wavelengths of different region of visible range. In this paper we report on comparative analysis of single- and dual-wavelength PDT regimes based on multimodal optical monitoring of tissue response with histologic verification. Morphological and functional tissue responses to PDT procedure with chlorin-based photosensitizer (PS) were studied at the normal skin of a rabbit ear inner surface. Multimodal optical monitoring was performed by OCT and dual-wavelength fluorescence technique. The studied doses vary from 50 to 150 J/cm2 delivered separately at 405 or 660 nm, or at both wavelengths together in the equal dose.
© 2019 SPIE/OSA
PDF ArticleMore Like This
Mikhail Kirillin, Maria Shakhova, Daria Kurakina, Aleksandr Khilov, Anna Orlova, Ekaterina Sergeeva, Alina Meller, Natalia Orlinskaya, and Ilya Turchin
11079_26 European Conference on Biomedical Optics (ECBO) 2019
Herbert Stepp, Gesa Kniebühler, Thomas Pongratz, Christian S. Betz, Burkhard Göke, Ronald Sroka, and Jörg Schirra
88030M European Conference on Biomedical Optics (ECBO) 2013
A.V. Khilov, D.A. Kurakina, I.V. Turchin, and M.Yu. Kirillin
11079_54 European Conference on Biomedical Optics (ECBO) 2019