Abstract

Visualization of the spatial distribution of nanoparticles in organs and tumors is a rapidly developing field in terms of diagnostics and therapy of oncological diseases. The method of imaging up-conversion nanoparticles in tissues and organs using a scanning system has become widespread. In this case, the exciting radiation is focused on the surface of the object, the luminescence is collected by a wide-aperture optical system and is recorded by a photodetector. The aim of this study was to register the spatial distribution of upconversion nanoparticles in sections of organs and tumors of laboratory animals in health and disease (liver cancer) using a fluorescent microscope. It was shown that upconversion nanoparticles accumulate mainly in the spleen, which is confirmed by the data of histopathological analysis. With a three-fold intravenous injection of particles, their maximum accumulation in the tumor tissue occurs. In general, the particles accumulated in the tumor and did not damage organs, tissues, or erythrocytes.

© 2021 The Author(s)