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Conferences > FiO > 2003 > ThPP > ThPP4

Probing the kinesin reaction cycle with a 2D optical force clamp

C.L. Asbury, J.W. Shaevitz, M.J. Lang, and S.M. Block

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Abstract

We developed an optical force clamp to apply loads to single molecules of kinesin moving on microtubule filaments. The effects of forward, backward, and sideways loads on kinesin motion suggest that the underlying reaction cycle contains a single working stroke that is well aligned with the direction of motion.

© 2003 Optical Society of America

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