Optical nanostructures provide hyper-resolution of single molecule dynamics

Watt W. Webb; Michael J. Levene

doi:10.1364/FIO.2003.ThR2

Frontiers in Optics
OSA Technical Digest (CD) (Optica Publishing Group, 2003),
paper ThR2
•https://doi.org/10.1364/FIO.2003.ThR2

Optical nanostructures provide hyper-resolution of single molecule dynamics

Watt W. Webb and Michael J. Levene

Frontiers in Optics 2003

Tucson, Arizona United States
5–8 October 2003
ISBN: 1-55752-759-8

From the session
Biomolecular Imaging Using Nonlinear Excitation II (ThR)

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W. W. Webb and M. J. Levene, "Optical nanostructures provide hyper-resolution of single molecule dynamics," in Frontiers in Optics, OSA Technical Digest (CD) (Optica Publishing Group, 2003), paper ThR2.

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Abstract

Because biological signals in vivo are frequently single molecule responses, individual molecular identities and fluctuations of enzyme chemical kinetics become essential challenges. Optical nanostructures allow zeptoliter focal volumes to reduce the number of substrate molecules seen to measure single enzyme fluctuations and to identify individual molecules in nanoscopic flows.

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