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Conferences > FiO > 2014 > FTu5E > FTu5E.1

Label-free assessment of mitochondrial organization in three-dimensional tissues

Irene Georgakoudi, Dimitra Pouli, Antonio Varone, Joanna Xylas, Kyle P. Quinn, Martin Hunter, Margaret E. McLaughlin-Drubin, and Karl Munger

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Abstract

A Fourier-based method can be used to analyze endogenous NADH two-photon excited fluorescence images to characterize quantitatively mitochondrial organization. This optical biomarker is sensitive to metabolic changes that may occur at the onset of disease.

© 2014 Optical Society of America

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