Abstract

This work reports on the use of Raman spectroscopy together with principal component analysis (PCA) in detecting the Human Immunodeficiency Virus (HIV) type 1 p24 antigen in human blood plasma. PCA distinguished Raman spectroscopic data patterns of plasma samples containing HIV1-p24 antigens from those without. The characteristic HIV1-p24 antigens Raman spectrum displayed broad bands centered at waveshifts 798, 1208, 1302 and 1526 cm⁻¹ upon excitation with light of wavelength centered at 785 nm similar to those reported elsewhere.

© 2016 Optical Society of America