Abstract
We report multiplexed label-free measurements of biomolecular interactions using silicon wire waveguide sensor arrays. The sensors are addressed using both wavelength division multiplexing and power broadcasting approaches. We demonstrate the real-time monitoring of antibody-antigen reactions using complementary and mismatched IgG receptor-analyte pairs and bovine serum albumin. The measured level of detection for each sensor element corresponds to a surface coverage of less than ~ 0.02% of a protein monolayer. The two addressing approaches are compared.
© 2010 Optical Society of America
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