Label-Free Biosensing by Ultrasensitive Supercritical Angle Refractometry

Lucien E. Weiss; Boris Ferdman; Boris Ferdman; Onit Alalouf; Yoav Shechtman

doi:10.1364/ISA.2019.ITh3B.2

Imaging and Applied Optics 2019 (COSI, IS, MATH, pcAOP)
OSA Technical Digest (Optica Publishing Group, 2019),
paper ITh3B.2
•https://doi.org/10.1364/ISA.2019.ITh3B.2

Label-Free Biosensing by Ultrasensitive Supercritical Angle Refractometry

Lucien E. Weiss, Boris Ferdman, Onit Alalouf, and Yoav Shechtman

Imaging Systems and Applications 2019

Munich Germany
24–27 June 2019
ISBN: 978-1-943580-63-7

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Biophotonics (ITh3B)

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L. E. Weiss, B. Ferdman, O. Alalouf, and Y. Shechtman, "Label-Free Biosensing by Ultrasensitive Supercritical Angle Refractometry," in Imaging and Applied Optics 2019 (COSI, IS, MATH, pcAOP), OSA Technical Digest (Optica Publishing Group, 2019), paper ITh3B.2.

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Abstract

By imaging the back focal plane of a fluorescence microscope, we demonstrate precise determination of a sample’s refractive index in a fluorophore-laden microfluidic device. We apply the technique to biosensing by detecting unlabeled bacteria.

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