Abstract

Photodynamic therapy (PDT) is a minimally invasive therapeutic procedure that can selectively destroy the tumor tissue with singlet oxygen. At present, we have investigated low-cost light source, light emitting diode (LED) for PDT as a light source. An LED array produces a spectral emission with a narrow bandwidth in the region of 5-20 nm. Considering the LED characteristic, it’s needed to analyze theoretically optimum PDT therapeutic dose with LED based on tissue optics. Fluence distribution is so important to evaluate PDT effective, and the fluence distribution depends on the tissue optical properties, i.e. absorption coefficient μa, scattering coefficient μs, anisotropy factor g, and refractive index. We study evaluation of PDT effective with tumor model prepared with tumor cells grown on the chorioallantoic membrane of chicken egg (CAM tumor model) which is a three dimensional tumor model. To estimate theoretically PDT effective, it is necessary to measure optical properties of CAM tumor tissues. Optical properties of mouse tumor tissues, which used in PDT preclinical test as a tumor model usually, are also needed to measure for the comparison with the CAM tumor. The purpose of this study is to determine optical properties of CAM and mouse tumor tissues, and compare them.

© 2013 Japan Society of Applied Physics, Optical Society of America