Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Label-free measurement of cell-electrode cleft gap distance with a high spatial resolution surface plasmon microscopy

Not Accessible

Your library or personal account may give you access

Abstract

Biointerface – an interface between bio- and non-bio-material – has been of great importance for broad range of areas such as medical or bioanalytical applications. In fundamental neuroscience and biomedical research, for extracellular recording in conjunction with rapidly advanced nanoelectronics, electric signal at a cellular membrane surface is measured noninvasively, incurring less damage to the cell and thus longer recording time. In such signal recording, the geometry between cells and electrodes is one of the key factors, especially the distance of cell membranes from electrodes, i.e. cleft gap distance. Up to now, the technique such as fluorescence or electron microscopy is widely used to investigate the interface [1,2]. However, observations with those microscopes require complicated and laborious sample pretreatment, e.g. staining, fixation dehydration or cutting. Furthermore these pretreatment may cause sample damage.

© 2014 Japan Society of Applied Physics, Optical Society of America

PDF Article
More Like This
Label-free cell organelle imaging by D-EXA microscopy

Yasunori Nawa, Wataru Inami, Atsushi Ono, Sheng Lin, Yoshimasa Kawata, and Susumu Terakawa
19a_C4_8 JSAP-OSA Joint Symposia (JSAP) 2014

Label-Free Confocal iSCAT Microscopy on Live Cells

Michelle Küppers, David Albrecht, Anna Kashkanova, Jennifer Lühr, and Vahid Sandoghdar
NTh2C.5 Novel Techniques in Microscopy (NTM) 2021

Mapping the Spatial Distribution of Cell Surface Receptors with Plasmon Coupling Microscopy

Hongyun Wang, Jing Wang, Guoxin Rong, and Björn M. Reinhard
FWL1 Frontiers in Optics (FiO) 2011

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved