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Fluorescence-Raman (Dual-modal) Endoscopic System for Real-time in vivo Multiplexed Molecular Diagnosis

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Abstract

Optical-based endoscopic imaging techniques have been intensively explored for use in the diagnosis of specific cancers involving gastric, lung, colon, and bladder cancer due to its accessibility to internal organs and real-time imaging with minimally invasive procedure. [1] However, subtle neoplastic changes are difficult to identify using solely conventional white light reflectance (WLR) endoscopy in flat and suspicious lesions because it can only distinguish visually observable morphological changes. For this reason, to improve the accuracy of endoscopic diagnosis in early stage of specific cancer, additional functionalities have been combined with endoscopic system such as fluorescence, bioluminescence, and Raman scattering. [2-3]

© 2014 Japan Society of Applied Physics, Optical Society of America

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