In recent years, the critical roles of physical & mechanical cell-cell interactions and cell-ECM (extra-cellular matrix) interactions in the physiological functions and the pathological status at the cellular level have received increasing attentions [1, 2]. Specifically, the studies of the cellular response to external physical, mechanical, and chemical stimuli in the context of Epithelial-Mesenchymal Transition (EMT) and the associated reversed process of Mesenchymal-Epithelial Transition (MET), which play an essential role in developmental biology, and in cancer metastasis as well as in stem cell differentiation [2-4], have shed light on the molecular pathways and/or mechanisms of these processes with important biomedical implications.
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