Abstract

Optical methodologies for sensing, imaging, or controlling biomolecules have been revealing mechanisms of various biological activities. Because many molecules work with interactions at a time in a biological system, it is necessary to deal with diverse molecules simultaneously or to manipulate much information on the molecules for effective analysis or control. Multi-channel fluorescence imaging is a good example to satisfy the demand. In-situ computation on molecules is another promising strategy because it offers, for example, encoding a set of information into a simplified code to support efficient sensing or imaging. It also enables to make physical or chemical reactions depending on the status of the target molecules at the positions where they exist. We are studying on photonic DNA computing, which is helpful to achieve in-situ computation on biomolecules based on DNA and photonics technologies. In this report, we present some implementing methods of photonic DNA computing for biomolecular sensing.

© 2015 Japan Society of Applied Physics, Optical Society of America