Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

A new method for Diagnosis of Early Prostate Cancer Based on the Enhancement of Blood Porphyrin

Not Accessible

Your library or personal account may give you access

Abstract

Substances such as porphyrin derivatives accumulate substantially more in tumors than in normal tissues. In this study, the autofluorescence of blood porphyrin was analyzed using fluorescence spectroscopy on healthy male NUDE mice and in those with prostate cancer induced by inoculation of DU145 cells. A total of 15 male NUDE mice, ~6 weeks old on arrival were divided into 3 groups: Control, Tumor and ALA Tumor. The autofluorescence of blood porphyrin of the groups was analyzed using fluorescence spectroscopy at one week, two weeks, three weeks, and five weeks after tumor induction. Emission spectra were obtained by exciting the samples at 405 nm. The animals inoculated had their blood collected with (ALA Tumor) and without (Tumor) oral administration of ALA solution to compared PPIX endogenous and exogenous signal intensity and to establish a method to diagnosis early prostate cancer. Significant differences were observed in autofluorescence intensities measured in the 575–725 nm spectral regions for the studied groups. The results shown an enhancement of PPIX from total blood animals that have received ALA solution when compared that haven’t had.

© 2010 Optical Society of America

PDF Article
More Like This
Z-scan technique: A new concept for Diagnosis of Prostate Cancer in blood

Camila T. Nabeshima, Sarah Isabel Pinto Alves, Antonio Martins F. Neto, Flávia R. O. Silva, Ricardo Elgul Samad, and Lilia C. Courrol
JTh2A.132 Frontiers in Optics (FiO) 2016

Fluorescence Spectroscopy: a noninvasive method for monitoring the treatment of metastatic renal cell carcinoma

Rodolfo Ferreira Marques, Marina de Souza Braga, Karen Cristina Barbosa Chaves, Camila Campanharo Barricheli, Cinthia Zanini Gomes, Lilia Coronato Courrol, and Maria Helena Bellini
PDPTuJ3 Latin America Optics and Photonics Conference (LAOP) 2010

5-Aminolevulinic Acid in Aqueous Gel - Effective Delivery System for ALA Based PDT

Nataliya A. Sakharova, Nataliya I. Kazachkina, Andrey A. Pankratov, Raisa I. Yakubovskaya, Nikolai V. Osikov, Vladimir M. Negrimovsky, Sergey G. Kuzmin, Evgeny A. Lukyanets, and Georgy N. Vorozhtsov
6632_62 European Conference on Biomedical Optics (ECBO) 2007

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved