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Imaging the Distribution of Melanin in Human Skin Lesions with Pump-Probe Microscopy

Mary Jane Simpson, Jesse W. Wilson, Thomas E. Matthews, Marco Duarte, Robert Calderbank, and Warren S. Warren

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Abstract

Melanoma diagnosis poses tremendous challenges in dermatopathology; recent studies show discordance rates in pathology as high as one in seven[1], and the severe consequences of missing a melanoma diagnosis has increased the number of biopsies taken and lowered the threshold for diagnosis of early melanoma[2]. This leads to unknown but likely significant societal costs and morbidity from associated unnecessary treatments.

© 2011 Optical Society of America

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