Abstract

The blood-brain barrier (BBB) is a unique barrier between the cerebral circulation and the brain tissue that maintains the delicate environment of the brain by limiting the entrance of molecules and ions from the blood stream. It is also widely known that the BBB in a neonate brain is still developing and its structure is not as complete as that in an adult. A new method was developed to quantify the BBB solute permeability postnatal rat brain and adult by using two-photon imaging system in vivo.

© 2016 Optical Society of America