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Characterization of Polymorphism in Sulfamethoxazole Pharmaceutical Molecule Using Terahertz Time-domain Spectroscopy

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Abstract

Absorption spectra in 0.2~1.5 THz region were measured for sulfamethoxazole pharmaceutical molecule with different polymorphic forms using time-domain terahertz spectroscopic technique. The observed THz absorption bands are strikingly sensitive to the change of subtle conformational structures within different polymorphs. The results show that the THz-TDS is a promising method in solid-state analytical tools to study polymorphism effect in pharmaceutical field.

© 2012 Optical Society of America

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