High contrast breast cancer biomarker imaging using upconverting nanoparticles

Sanathana Konugolu Venkata Sekar; Hui Ma; Hui Ma; Katarzyna Komolibus; Gokhan Dumlupinar; Gokhan Dumlupinar; Krzysztof Krawczyk; Matthias Mickert; Stefan Andersson-Engels; Stefan Andersson-Engels

doi:10.1364/TRANSLATIONAL.2022.JM1A.4

Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Technical Digest Series (Optica Publishing Group, 2022),
paper JM1A.4
•https://doi.org/10.1364/TRANSLATIONAL.2022.JM1A.4

High contrast breast cancer biomarker imaging using upconverting nanoparticles

Sanathana Konugolu Venkata Sekar, Hui Ma, Katarzyna Komolibus, Gokhan Dumlupinar, Krzysztof Krawczyk, Matthias Mickert, and Stefan Andersson-Engels

Microscopy Histopathology and Analytics 2022

Fort Lauderdale, Florida United States
24–27 April 2022
ISBN: 978-1-957171-03-6

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Joint Postdeadline Papers (JM1A)

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S. K. V. Sekar, H. Ma, K. Komolibus, G. Dumlupinar, K. Krawczyk, M. Mickert, and S. Andersson-Engels, "High contrast breast cancer biomarker imaging using upconverting nanoparticles," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper JM1A.4.

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Abstract

Breast cancer is a leading cause of death in women and has scope for improvement in treatment stratification. We report the use of high contrast UCNP staining to distinguish different levels of HER2 expression in HER2 analyte control and HER2-positive breast cancer tissue biopsies. A contrast of 40 was found as compared to the negative control and 25 as compared to conventional DAB staining.

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