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Super-resolution imaging of chromatin ultrastructure in cancer pathogenesis using small-molecule fluorescent probe

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Abstract

We present the development of a fast and simple small-molecule fluorescent DNA stain for routine use of stochastic optical reconstruction microscopy (STORM) on clinically prepared tissue samples. We demonstrated its significance in imaging super-resolved chromatin structure at various stages of cancer development from human tissue samples.

© 2022 The Author(s)

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