Abstract

Since many diseases of the retina result in changes in retinal circulation, information on hemodynamics can be important in the diagnosis and the evaluation of current and new therapies. We are developing a method that would allow repeated mapping of the hemodynamics of the retinal macro- and micro-circulation. The method, named targeted dye delivery, consists of encapsulating a fluorescent dye in temperature sensitive liposomes, injecting them systemically and releasing a bolus of dye in a targeted retinal vessel by a light pulse from an argon laser. We report here on the evaluation of the method in the study of retinal hemodynamics of a primate.

© 1990 Optical Society of America