Potential information gains from superresolution with correlated emitters

Alex Small; Derrick Ortiz; Michael Samson

doi:10.1364/NTM.2015.NM2C.1

Optics in the Life Sciences
OSA Technical Digest (online) (Optica Publishing Group, 2015),
paper NM2C.1
•https://doi.org/10.1364/NTM.2015.NM2C.1

Potential information gains from superresolution with correlated emitters

Alex Small, Derrick Ortiz, and Michael Samson

Novel Techniques in Microscopy 2015

Vancouver Canada
12–15 April 2015
ISBN: 978-1-55752-954-1

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Super Resolution I (NM2C)

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A. Small, D. Ortiz, and M. Samson, "Potential information gains from superresolution with correlated emitters," in Optics in the Life Sciences, OSA Technical Digest (online) (Optica Publishing Group, 2015), paper NM2C.1.

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Abstract

We theoretically analyze information gains from using correlated (but spectrally distinct) fluorophores in superresolution localization microscopy at high labeling densities. Imaging with pairs of anti-correlated fluorophores reduces biases in estimation of fluorophore spacing.

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