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Optica Publishing Group
  • Biophotonics Congress: Optics in the Life Sciences 2023 (OMA, NTM, BODA, OMP, BRAIN)
  • Technical Digest Series (Optica Publishing Group, 2023),
  • paper JW2A.3
  • https://doi.org/10.1364/BODA.2023.JW2A.3

Breaking new ground in protein detection: Self-supervised machine learning and iSCAT enable label-free detection of single proteins below 10 kDa

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Abstract

Interferometric scattering (iSCAT) microscopy detects single nanoparticles in a label-free fashion. Utilizing self-supervised machine learning pushes the detection sensitivity of iSCAT to very small proteins and disease markers such as chemokines and cytokines.

© 2023 The Author(s)

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