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Fiber Light-coupled Optofluidic Waveguide (FLOW) immunosensor for p53 protein detection in serum

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Abstract

Fiber light-coupled optofluidic waveguide (FLOW) immunosensor is demonstrated, for highly sensitive, specific detection of a typical tumor biomarker (p53 protein) in serum. The optofluidic waveguide consists of a liquid-filled capillary and a light-coupling microfiber in lateral contact, which allows strong evanescent-wave interaction between light and microfluidics. The immunosensor presents extremely high detection limit at 0.11 fg/mL, by measuring the binding induced shift of the transmission spectrum. This immunosensor works in “flow mode”, in which the flowing fluid at optimal velocity can effectively remove nonspecifically adsorbed biomolecules. Serum test result shows that the sensitivity and specificity can be well maintained. The advanced capability of the FLOW sensor makes it suitable for further applications in early-stage cancer diagnostics.

© 2018 The Author(s)

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