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AFM-Fiber based infrared nanospectroscopy for facilitating the application on protein aggregation

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Abstract

Infrared nanospectroscopy is a newly developed technique for biochemical and biophysical analysis on various areas by providing the structural information of the molecular level, as well as the morphological and mechanical information from AFM image of the sample simultaneously. However, minimization of the platform is critical for this powerful technique in the following applications of, for instance, contributing the improvement of the protein aggregation study from in vitro to in vivo in psychological condition. Here, we take the first step and demonstrate a compact infrared fiber based platform to monitor the protein amyloidosis from monomeric and oligomeric aggregates to mature amyloid fibril, with infrared absorption of protein self-assembly in nanoscale level. These efforts can be developed to a method for measuring, monitoring and possibly treating in medical usage of the neurodegeneration diseases.

© 2018 The Author(s)

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