Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

Tip enhanced Raman Spectroscopy (TERS) Instrumentation for the Probing of Linearized DNA for Cancer-Specific Lesions: Challenges and Outcomes

Not Accessible

Your library or personal account may give you access

Abstract

The progression of a cell from normal function to the unchecked replication observed in malignant cancers is advanced by various environmental or internal processes which damage cellular DNA. Whether DNA damage is a “first-mover” causative agent or a secondary step in a cascade of cellular processes differs from case to case. Damage to DNA’s integrity, however, is common to all cancers and many diseases in general. Modification sites on polynucleotides, commonly referred to as lesions, often take the form of minor changes in the molecular structure or conformation of the nucleobase. Locating these changes in the DNA sequence of single molecules is difficult because they largely cannot be assayed by conventional sequencing techniques. A potentially powerful solution to this problem is offered by the TERS technique, which conventionally provides resolutions on the order of 10 nm, but whose resolution, in theory, can be improved to the single-base stacking distance by utilizing principles of super-resolution.

© 2011 Optical Society of America

PDF Article
More Like This
Tip-Enhanced Raman Spectroscopy: Focusing in on a Direct Sequencing Method for Oxidized DNA

Noah J. Kolodziejski, Rajan Gurjar, Karthik Vishwanath, and David Wolf
BT3A.29 Biomedical Optics (BIOMED) 2014

Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people

Xiaozhou Li, Tianyue Yang, Siqi Li, and Ting Yu
808722 European Conference on Biomedical Optics (ECBO) 2011

Near-Infrared Raman Spectroscopy for Detection of Gastric Cancer Peritoneal Dissemination in vivo

Ma Jun, Mao Wei-zheng, Xu Ming, Gong Long-jing, Gao Yuan, Zhou Han-jing, and Zheng Rong-er
808714 European Conference on Biomedical Optics (ECBO) 2011

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved