99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy

Viviana Frantellizzi; Mariano Pontico; Giuseppe De Vincentis; Liana Civitelli; Francesca Petronella; Roberto Pani; Antonella Calogero; Giovanni Perotto; Luciano De Sio

doi:10.1364/OMP.2021.OTu1E.5

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper OTu1E.5
•https://doi.org/10.1364/OMP.2021.OTu1E.5

^99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy

Viviana Frantellizzi, Mariano Pontico, Giuseppe De Vincentis, Liana Civitelli, Francesca Petronella, Roberto Pani, Antonella Calogero, Giovanni Perotto, and Luciano De Sio

Optical Molecular Probes, Imaging and Drug Delivery 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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Molecular Contrast Agents and Probes (OTu1E)

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V. Frantellizzi, M. Pontico, G. De Vincentis, L. Civitelli, F. Petronella, R. Pani, A. Calogero, G. Perotto, and L. De Sio, "99mTc-labeled Keratin-coated gold nanoparticles for selective anticancer photothermal therapy," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper OTu1E.5.

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Abstract

We report and discuss the synthesis and characterization of a new generation of radiolabeled ^99mTc keratin gold nanoparticles (^99mTc-Ker-AuNPs) to realize a new generation of biocompatible nanotherapeutics for the treatment of cancerous tissues via light assisted thermal therapy. The presence of ^99mTc easily allows revealing the Ker-AuNPs accumulation in tissues, thus enabling a selective photothermal ablation. The ^99mTc-Ker-AuNPs is investigated through instant thin-layer chromatography (ITLC), UV-Vis spectroscopy, and a high resolution thermographic optical setup, revealing a successful conjugation between ^99mTc-Ker and Ker-AuNPs along with excellent photo-thermal properties.

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