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Conferences > OMP > 2021 > OTu3D > OTu3D.3

NIR dye antibody conjugates for molecular photoacoustic imaging and photodynamic therapy

Srivalleesha Mallidi, Mohammad A. Saad, Robert Pawle, Marvin Xavierselvan, Larry Takiff, and Tayyaba Hasan

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Abstract

Here we present a dual function antibody conjugate with a photosensitizer (or a fluorophore) and a napthalocyanine dye conjugated on Cetuximab targeted towards Epidermal growth factor receptor. The in vitro therapeutic efficacy and in vivo molecular photoacoustic imaging capabilities of the conjugate are demonstrated in murine oral cancer models.

© 2021 The Author(s)

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