In Vivo Labeling and Enumeration of Circulating Tumor Cells with a Folate-Receptor Targeted Molecular Probe

Joshua Pace; Fernando Ivich; Roshani A. Patil; Srinivasarao Madduri; Mansoor M. Amiji; Philip S. Low; Mark Niedre

doi:10.1364/OMP.2021.OW3E.2

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper OW3E.2
•https://doi.org/10.1364/OMP.2021.OW3E.2

In Vivo Labeling and Enumeration of Circulating Tumor Cells with a Folate-Receptor Targeted Molecular Probe

Joshua Pace, Fernando Ivich, Roshani A. Patil, Srinivasarao Madduri, Mansoor M. Amiji, Philip S. Low, and Mark Niedre

Optical Molecular Probes, Imaging and Drug Delivery 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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Pre-Clinical Fluorescence Molecular Imaging (OW3E)

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J. Pace, F. Ivich, R. A. Patil, S. Madduri, M. M. Amiji, P. S. Low, and M. Niedre, "In Vivo Labeling and Enumeration of Circulating Tumor Cells with a Folate-Receptor Targeted Molecular Probe," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper OW3E.2.

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Abstract

We used a folate-receptor targeted fluorescent molecular probe to label circulating tumor cells directly in the bloodstream in mouse metastasis models. We used a new diffuse light-based optical instrument to non-invasively detect and count them.

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