Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures

Connor W. Barth; Lei G. Wang; Antonio Montano; Alexander L. Antaris; Alwin Klaassen; Jonathan Sorger; Darcy A. Kerr; Darcy A. Kerr; Eric R. Henderson; Adam W. G. Alani; Adam W. G. Alani; Summer L. Gibbs; Summer L. Gibbs

doi:10.1364/OMP.2021.OW3E.3

Biophotonics Congress 2021
OSA Technical Digest (Optica Publishing Group, 2021),
paper OW3E.3
•https://doi.org/10.1364/OMP.2021.OW3E.3

Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures

Connor W. Barth, Lei G. Wang, Antonio Montano, Alexander L. Antaris, Alwin Klaassen, Jonathan Sorger, Darcy A. Kerr, Eric R. Henderson, Adam W. G. Alani, and Summer L. Gibbs

Optical Molecular Probes, Imaging and Drug Delivery 2021

Washington, DC United States
12–16 April 2021
ISBN: 978-1-943580-85-9

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Pre-Clinical Fluorescence Molecular Imaging (OW3E)

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C. W. Barth, L. G. Wang, A. Montano, A. L. Antaris, A. Klaassen, J. Sorger, D. A. Kerr, E. R. Henderson, A. W. G. Alani, and S. L. Gibbs, "Lead Optimization of Nerve-Specific Fluorophores for Image-Guided Nerve Sparing Surgical Procedures," in Biophotonics Congress 2021, C. Boudoux, K. Maitland, C. Hendon, M. Wojtkowski, K. Quinn, M. Schanne-Klein, N. Durr, D. Elson, F. Cichos, L. Oddershede, V. Emiliani, O. Maragò, S. Nic Chormaic, N. Pégard, S. Gibbs, S. Vinogradov, M. Niedre, K. Samkoe, A. Devor, D. Peterka, P. Blinder, and E. Buckley, eds., OSA Technical Digest (Optica Publishing Group, 2021), paper OW3E.3.

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Abstract

Nerve damage is a major complication of surgery, causing pain and loss of function. We have identified novel near-infrared nerve-specific fluorophores that provide excellent nerve contrast with the ability to identify buried nerve tissue.

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