Concentration independent modulation of local micromechanics in a fibrin clot

Maxwell A. Kotlarchyk; Maxwell A. Kotlarchyk; Samir G. Shreim; Samir G. Shreim; Martha B. Alvarez-Elizondo; Martha B. Alvarez-Elizondo; Elliot L. Botvinick; Elliot L. Botvinick

doi:10.1364/OTA.2011.OTMC6

Optics in the Life Sciences
OSA Technical Digest (CD) (Optica Publishing Group, 2011),
paper OTMC6
•https://doi.org/10.1364/OTA.2011.OTMC6

Concentration independent modulation of local micromechanics in a fibrin clot

Maxwell A. Kotlarchyk, Samir G. Shreim, Martha B. Alvarez-Elizondo, and Elliot L. Botvinick

Optical Trapping Applications 2011

Monterey, California United States
4–6 April 2011
ISBN: 978-1-55752-909-1

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Analysis of Biological Systems (OTMC)

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M. A. Kotlarchyk, S. G. Shreim, M. B. Alvarez-Elizondo, and E. L. Botvinick, "Concentration independent modulation of local micromechanics in a fibrin clot," in Optics in the Life Sciences, OSA Technical Digest (CD) (Optica Publishing Group, 2011), paper OTMC6.

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Abstract

Optical tweezers active microrheology (AMR) probes microdomain mechanical properties in 3D engineered tissues. The application of a nonuniform strain field setups up distributed stiffness, measured by AMR, which yields differential cell phenotypes.

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