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Clinical Significance of in - vitro MTF: Phenomenological Model

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Abstract

In 1965, Campbell and Green made use of the concept that the MTF of the human dioptric could be inferred from the ratio of sign-wave to interferometric contrast sensitivity measurements1. Below, we employ the same procedure, in reverse, to suggest a phenomenological algorithm for predicting the "clinical significance" (e.g., letter or sign-wave contrast sensitivity) of changes made to the human dioptric (e.g., multifocal IOL implant). This algorithm can also be used to predict the Through- Focus-Capability (acuity v.s. defocus), with the potential for studying expected changes with light intensity and object contrast. A comparison of predictions to early clinical data derived from Allergan's randomized AMO ArrayTM multifocal clinical study, demonstrates the plausibility of this approach.

© 1992 Optical Society of America

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