Singel molecule fluorescence spectroscopy couples with cell imaging and solid state NMR to reveal the earliest events in Alzheimer's disease

Sudipta Maiti

doi:10.1364/PHOTONICS.2012.W3B.1

International Conference on Fibre Optics and Photonics
OSA Technical Digest (online) (Optica Publishing Group, 2012),
paper W3B.1
•https://doi.org/10.1364/PHOTONICS.2012.W3B.1

Singel molecule fluorescence spectroscopy couples with cell imaging and solid state NMR to reveal the earliest events in Alzheimer's disease

Sudipta Maiti

International Conference on Fibre Optics and Photonics 2012

Chennai India
9–12 December 2012
ISBN:

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Biophotonics II (W3B)

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S. Maiti, "Singel molecule fluorescence spectroscopy couples with cell imaging and solid state NMR to reveal the earliest events in Alzheimer's disease," in International Conference on Fibre Optics and Photonics, OSA Technical Digest (online) (Optica Publishing Group, 2012), paper W3B.1.

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Abstract

The earliest detectable transformation in Alzheimer's is the transition from monomers to oligomers of amyloid beta. We have discovered an aggregation related structural transition that seems to strongly alter the bio-acitivity of this species.

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