Abstract

Techniques for diagnosis and management of neoplasia have advanced considerably, offering patients better management and more treatment alternatives. Endoscopy, x-ray Computed Tomography (CT) and Magnetic Resonance Imaging (MRI) have provide the clinician with an additional set of indications and augment the accuracy of excisional biopsies. However, early neoplastic changes, remain beyond the detection limits of these modalities. The diagnosis of early cancer is still based mostly on biopsy identification of structural and cellular changes associated with the disease. A technology capable of imaging tissue, at or near the cellular level, could lead to the detection of pathology at earlier stages than currently possible. This could significantly improve patient outcomes, since once metastatic, cure is difficult.

© 1999 Optical Society of America