Rapid, point-of-care, thermally stable paper-based plasmonic assay for Zika virus diagnosis

Qisheng Jiang; Yatin J. Chandar; Sisi Cao; Evan D. Kharasch; Evan D. Kharasch; Evan D. Kharasch; Evan D. Kharasch; Srikanth Singamaneni; Srikanth Singamaneni; Jeremiah J. Morrissey; Jeremiah J. Morrissey

doi:10.1364/SENSORS.2017.SeTu1E.2

Advanced Photonics 2017 (IPR, NOMA, Sensors, Networks, SPPCom, PS)
OSA Technical Digest (online) (Optica Publishing Group, 2017),
paper SeTu1E.2
•https://doi.org/10.1364/SENSORS.2017.SeTu1E.2

Rapid, point-of-care, thermally stable paper-based plasmonic assay for Zika virus diagnosis

Qisheng Jiang, Yatin J. Chandar, Sisi Cao, Evan D. Kharasch, Srikanth Singamaneni, and Jeremiah J. Morrissey

Optical Sensors 2017

New Orleans, Louisiana United States
24–27 July 2017
ISBN: 978-1-943580-30-9

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Optical Chemical and Biological Sensors I (SeTu1E)

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Q. Jiang, Y. J. Chandar, S. Cao, E. D. Kharasch, S. Singamaneni, and J. J. Morrissey, "Rapid, point-of-care, thermally stable paper-based plasmonic assay for Zika virus diagnosis," in Advanced Photonics 2017 (IPR, NOMA, Sensors, Networks, SPPCom, PS), OSA Technical Digest (online) (Optica Publishing Group, 2017), paper SeTu1E.2.

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Abstract

We devised innovative, adaptable, bioplasmonic paper-based devices (BPDs) that diagnose Zika infection in patient serum via optical quantification of the localized surface plasmon resonance shift due to binding of patient’s anti-ZIKV-Nonstructural protein-1 IgG and IgM. By means of metal organic framework (MOF) technology, these BPDs do not require refrigeration and are stable at ambient temperature for extended time allowing use in resource-limited settings.

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