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Fibre-based ratiometric fluorescence imaging for contrast enhancement of spectrally similar signals in the lung

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Abstract

We present a widefield ratiometric fibred optical endomicroscopy platform capable of enhancing contrast between spectrally similar pathologically relevant fluorophores. We demonstrate the detection of fluorescently labelled bacteria in an autofluorescent ex vivo human lung model.

© 2020 The Author(s)

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More Like This
Time-resolved single photon spectroscopy for optical fibre-based sensing of bacterial infections in the distal lung

K. Ehrlich, S. Duncan, T. R. Choudhary, B. Mills, R. R. Thomson, R. K. Henderson, M. Bradley, K. Dhaliwal, and M. G. Tanner
TTu2B.3 Clinical and Translational Biophotonics (Translational) 2020

Fibre Platform for Multiplexed Physiological Sensing in the Distal Lung with Fluorescent Probes on Multicore Fibres

M. G. Tanner, T. R. Choudhary, K. Ehrlich, A. Megia-Fernandez, K. Harrington, H. A. Wood, A. Marshall, P. Zhu, S. V. Chankeshwara, D. Choudhury, G. Monro, M. Ucuncu, F. Yu, R. R. Duncan, R. R. Thomson, K. Dhaliwal, and M. Bradley
TTu2B.2 Clinical and Translational Biophotonics (Translational) 2020

In-vivo Fluorescence Imaging of Bacterial Infection in the Mouse Lung

Fatemeh Nooshabadi, Hee-jeong Yang, Jeffrey D. Cirillo, and Kristen C. Maitland
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