Experimental and numerical tools to guide the controlled photothermal therapy in preclinical glioblastoma models

Antoine Capart; Khaled Metwally; Khaled Metwally; Chiara Bastiancich; Anabela Da Silva

doi:10.1364/TRANSLATIONAL.2022.JTu3A.5

Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN)
Technical Digest Series (Optica Publishing Group, 2022),
paper JTu3A.5
•https://doi.org/10.1364/TRANSLATIONAL.2022.JTu3A.5

Experimental and numerical tools to guide the controlled photothermal therapy in preclinical glioblastoma models

Antoine Capart, Khaled Metwally, Chiara Bastiancich, and Anabela Da Silva

Clinical and Translational Biophotonics 2022

Fort Lauderdale, Florida United States
24–27 April 2022
ISBN: 978-1-957171-03-6

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Joint Poster Session II Virtual (JTu3A)

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A. Capart, K. Metwally, C. Bastiancich, and A. Da Silva, "Experimental and numerical tools to guide the controlled photothermal therapy in preclinical glioblastoma models," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper JTu3A.5.

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Abstract

An experimental multifunctional set-up has been developed to perform pho-tothermal therapy in mice brain with blood-brain barrier opening by focused ultrasound sonication and in situ temperature monitoring with photoacoustic imaging. Additionally, a multiphysics numerical plateform has been set up to simulate the experiments in silico, in a highly realistic situation. These two tools help to identify the important parameters involved in the efficiency of a photothermal treatment.

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