Engineering cost function for optimizing coherent control between processes with different nonlinearities

J. Chen; Y. Nabekawa; K. Midorikawa; H. Kawano; H. Mizuno; A. Miyawaki; T. Tanabe; F. Kannari

14th International Conference on Ultrafast Phenomena
Technical Digest (CD) (Optica Publishing Group, 2004),
paper WB3

Engineering cost function for optimizing coherent control between processes with different nonlinearities

J. Chen, Y. Nabekawa, K. Midorikawa, H. Kawano, H. Mizuno, A. Miyawaki, T. Tanabe, and F. Kannari

International Conference on Ultrafast Phenomena 2004

Niigata Japan
25–30 July 2004
ISBN: 3-54024-110-8

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J. Chen, Y. Nabekawa, K. Midorikawa, H. Kawano, H. Mizuno, A. Miyawaki, T. Tanabe, and F. Kannari, "Engineering cost function for optimizing coherent control between processes with different nonlinearities," in 14th International Conference on Ultrafast Phenomena, Technical Digest (CD) (Optica Publishing Group, 2004), paper WB3.

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Abstract

Multiphoton fluorescence microscopy offers ability of imaging thick samples with enhanced longitudinal resolution, but suffers from issues of photobleaching and phototoxicity. It has been known that three-photon absorption of DNA is one of the causes of phototoxicity. Here, we apply coherent control to enhance the contrast between the two-photon absorption of fluorescent label and the three-photon absorption of biomaterial with engineered cost function, leading to effectively reduced three-photon absorption without loss of valuable two-photon fluorescence.

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