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Retinitis pigmentosa affects cone phototransduction as well as post-synaptic cone activity

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Abstract

Numerous reports have documented delays in the implicit times of the b-wave of the cone ERG in patients with retinitis pigmentosa (RP) (see ref 1 for review). Abnormalities of the cone a-wave combined with anatomical evidence have lead to the proposal that the cone ERG abnormalities are due, at least in part, to cone photoreceptor abnormalities, specifically to shortened outer segmentse.g.1-3. Other ERG evidencee.g.4-7 is more difficult to explain by a cone receptor defect.

© 1995 Optical Society of America

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