Expand this Topic clickable element to expand a topic
Skip to content
Optica Publishing Group

The Rising Phase of Rod Photocurrent is Fitted by a Linear Model of the Molecular Cascade with No Absolute Delay

Not Accessible

Your library or personal account may give you access

Abstract

A good understanding of the mechanisms of rod transduction is important in the diagnosis of retinal diseases affecting rod function. One well-characterized transduction pathway is that of vertebrate phototransduction, as exemplified by the analysis by of the activation processes in rod phototransduction based on biophysical and biochemical considerations. Taking such an approach to the analysis of salamander rod photocurrent responses, Lamb & Pugh (1992) conclude that the rising phase is well-described as an absolute delay followed by an inverted Gaussian acceleration. This model has been shown to provide a good fit to the rising phase of the photocurrent in amphibian rods (Lamb & Pugh, 1992), as well as to the rising phase of the a-wave of the ERG in humans (Hood & Birch, 1993; Hood & Birch, 1994; Breton et al., 1994). The model was linear up to ~104 photoisomerizations (Φ) per flash, above which progressive nonlinear changes in the model parameters were required to fit the data.

© 1996 Optical Society of America

PDF Article
More Like This
Intensity Dependence of cGMP Models Applied to A-Wave Leading Edge

M.E. Breton, E.N. Pugh, and A.W. Schueller
TuA2 Noninvasive Assessment of the Visual System (NAVS) 1992

Decline in ERG Maximum a-wave and b-wave Amplitudes with Age

Michael E. Breton and Monica B. Patel
TuB1 Vision Science and its Applications (VSIA) 1995

Biochemical representation of the ERG a-wave rising phase

M. E. Breton, E. N. Pugh, A. W. Schueller, and D. P. Montzka
TuWW4 OSA Annual Meeting (FIO) 1991

Select as filters


Select Topics Cancel
© Copyright 2024 | Optica Publishing Group. All Rights Reserved