Abstract
A good understanding of the mechanisms of rod transduction is important in the diagnosis of retinal diseases affecting rod function. One well-characterized transduction pathway is that of vertebrate phototransduction, as exemplified by the analysis by of the activation processes in rod phototransduction based on biophysical and biochemical considerations. Taking such an approach to the analysis of salamander rod photocurrent responses, Lamb & Pugh (1992) conclude that the rising phase is well-described as an absolute delay followed by an inverted Gaussian acceleration. This model has been shown to provide a good fit to the rising phase of the photocurrent in amphibian rods (Lamb & Pugh, 1992), as well as to the rising phase of the a-wave of the ERG in humans (Hood & Birch, 1993; Hood & Birch, 1994; Breton et al., 1994). The model was linear up to ~104 photoisomerizations (Φ) per flash, above which progressive nonlinear changes in the model parameters were required to fit the data.
© 1996 Optical Society of America
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