Add to BibSonomyAbstract
In this study, we investigate the performance of early-photon fluorescence tomography based on a heterogeneous mouse model. The telegraph equation is used to accurately describe the propagation of light in tissues at short times. The optimal time gate for early photons is determined by singular value analysis at first. Then, fluorescent targets located in different organs of the mouse model are investigated. The simulation results demonstrate that the reconstructed tomographic images based on early photons yield improvement in spatial resolution and quantification than the quasi-CW measurements. Meanwhile, compared with the homogeneous model, the use of the heterogeneous model can improve the accuracy of fluorescence distribution and quantification in early-photon fluorescence tomography.
© 2011 Optical Society of America
Full Article | PDF ArticleMore Like This
Frederic Leblond, Hamid Dehghani, Dax Kepshire, and Brian W. Pogue
J. Opt. Soc. Am. A 26(6) 1444-1457 (2009)
Jin Chen, Vivek Venugopal, and Xavier Intes
Biomed. Opt. Express 2(4) 871-886 (2011)
Junting Liu, Yabin Wang, Xiaochao Qu, Xiangsi Li, Xiaopeng Ma, Runqiang Han, Zhenhua Hu, Xueli Chen, Dongdong Sun, Rongqing Zhang, Duofang Chen, Dan Chen, Xiaoyuan Chen, Jimin Liang, Feng Cao, and Jie Tian
Opt. Express 18(12) 13102-13113 (2010)